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Pongpak Intaravichai. Kisspeptinneurokinin BDynorphin (KNDy) peptide mRNA expressions in intact female goats induced metabolic stress condition by facting. Master's Degree(Veterinary Clinical Studies). Kasetsart University. Office of the University Library. : Kasetsart University, 2019.
Kisspeptinneurokinin BDynorphin (KNDy) peptide mRNA expressions in intact female goats induced metabolic stress condition by facting
Name: Pongpak Intaravichai
Classification :.LCCS: SF768.2.G6
LCSH:
Goats
-- Reproduction
LCSH:
Gene expression
LCSH:
Kisspeptin neurons
LCSH:
Tachykinins
LCSH:
Dynorphin
LCSH:
Messenger RNA
Abstract:
The aims of this study are to ascertain the expression of KNDy peptide mRNA in the arcuate nucleus as well as to determine the effect of neurokinin B receptor agonist (senktide) on luteinizing hormone secretion and the ARC Kiss1 mRNA expression during the luteal phase of intact female goats induced metabolic stress conditions by fasting. All of the experiments were conducted on intact female goats during the luteal phase of estrus cycle which were fed by a standard diet throughout the experimental period (control group, n=2), fasted for 4 days (fasted group, n=2), and fasted for 4 days with senktide administration (treatment group, n=2). Our findings illustrated that four days of fasting led to approximately 1.7 kg of body weight loss. Mean serum NEFA (1.42 mM vs. 0.05 mM) and BHBA (0.62 mM vs. 0.36 mM) concentration in all fasted goats appeared to be higher than in fed goats. Mean serum LH concentration in the fed group was significantly higher (P<0.05) than in both fasted and fasted + senktide groups, which correlated with the KNDy peptides mRNA expression levels. The normalized relative expression level of Kiss1 and Pdyn in both fasted and fasted + senktide groups were significantly less than in the fed group, while the significant difference of normalized relative expression of Tac3 between three groups was not observed. Furthermore, senktide was not able to increase the ARC Kiss1 mRNA expression, nor to ameliorate fasting-induced LH suppression in fasted + senktide group. Consequently, under metabolic stress condition induced by fasting and being considerably influenced by progesterone hormone during mid to late luteal phase, several metabolic information substantially suppressed the ARC Kiss1 mRNA expression without altering Tac3 mRNA expression resulting in a decrease of mean LH concentration.
Kasetsart University. Office of the University Library
Address:
Bangkok
Email:
tdckulib@ku.ac.th
Name: Theera Rukkwamsuk
Role:
Thesis Advisor
Name: Somchai Sajapitak
Role:
Thesis CO-Advisor
Created:
2019
Modified:
2025-08-05
Issued:
2025-08-05
วิทยานิพนธ์/Thesis
application/pdf
URL: https://www.lib.ku.ac.th/KUthesis/2562/pongpak-int-all.pdf
CallNumber:
SF768.2.G6 .P66
eng
DegreeName: Master of Science
Level: Master's Degree
Descipline: Veterinary Clinical Studies
Grantor: Kasetsart University
©copyrights Kasetsart University
RightsAccess:
ใช้เวลา
0.027967 วินาที
Pongpak Intaravichai
| Title | Contributor | Type |
|---|---|---|
| Kisspeptinneurokinin BDynorphin (KNDy) peptide mRNA expressions in intact female goats induced metabolic stress condition by facting
มหาวิทยาลัยเกษตรศาสตร์ Pongpak Intaravichai | Theera Rukkwamsuk | วิทยานิพนธ์/Thesis |
Theera Rukkwamsuk
Somchai Sajapitak
| Title | Creator | Type and Date Create |
|---|---|---|
| Influence of a stress condition on growth and hypothalamic kiss1 mRNA expression in prepubertal gilts supplemented with fermented Potato protein
มหาวิทยาลัยเกษตรศาสตร์ Somchai Sajapitak | Sittipoj Krasaesub | วิทยานิพนธ์/Thesis |