Effects of intranasal or intramuscular Dexmedetomidine in Cats receiving total intravenous propofol anesthesia

Name: Kewvaree Hommuang

keyword: Dexmedetomidine.

LCSH: Kasetsart University -- Theses. M.S. (Veterinary Clinical Studies) 2021

Classification :.LCCS: SF985

LCSH: Kasetsart University. -- Department of Veterinary Medicine -- Theses

LCSH: Cats -- Diseases -- Treatment

LCSH: Veterinary anesthesia

LCSH: Drug interactions

LCSH: Veterinary drugs

LCSH: Drugs -- Overdose

LCSH: Injections, Intramuscular

Abstract: The purpose of the present study was to compare the perioperative and sparing effects of intranasal ( IN) and intramuscular ( IM) dexmedetomidine administration on propofol requirements for anesthetic induction in cats. Sixteen cats were randomly assigned to two groups to receive 20 μg/kg of dexmedetomidine administered by an IN or IM route. Sedation scores and side effects were recorded at time points 0 (T0), 5 (T5), 10 (T10), 15 (T15), and 20 (T20) minutes after the administration of dexmedetomidine. Anesthesia was induced with IV 1% propofol by titrating a bolus of 2 mg every 45 seconds and the total dose of intravenous propofol administered to achieve endotracheal intubation was recorded. Cats receiving IM dexmedetomidine were significantly associated with higher sedation scores. All cats were sedated at 20 minutes after premedication, nevertheless, average composite sedation scores in the IN group were significantly lower than those in the IM group during premedication. Preoperative side effects including vomiting were observed in the IN group (5 cats, 62.5% ) more frequently than in the IM group ( 3 cats, 37.5% ; p < 0.05) . Higher body temperature (>1°F compared to baseline) was observed more frequently in the IN group (6 cats, 75.0% ) than in the IM group (1 cat, 12.5%; p < 0.05). The dosage of propofol required in the IN group was significantly higher (1.1±0.3 mg/kg) than that required in the IM group ( 0. 7±0. 2 mg/ kg; p < 0. 05) . The duration of general anesthesia was comparable between the groups. The present study provides evidence that intranasal administration of dexmedetomidine produces moderate sedation, and cats may have some side effects, including vomiting and higher body temperature. Higher sparing effects of propofol were identified in the IM group compared with the IN group. Nonetheless, IN administration of dexmedetomidine provides a noninvasive alternative to the IM route.

Kasetsart University. Office of the University Library

Address: Bangkok

Email: tdckulib@ku.ac.th

Name: Naris Thengchaisri

Role: Thesis Advisor

Name: Panpicha Sattasathuchana

Role: Thesis CO-Advisor

Created: 2021

Modified: 2025-07-20

Issued: 2025-07-20

วิทยานิพนธ์/Thesis

application/pdf

URL: https://www.lib.ku.ac.th/KUthesis/2564/kewvaree-hom-all.pdf

CallNumber: SF985 .K49

eng

DegreeName: Master of Science

Level: Master's Degree

Descipline: Veterinary Clinical Studies

Grantor: Kasetsart University

©copyrights Kasetsart University

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