Biological activities of secondary metabolites homalium bhamoense cubitt & WWSm (Salicaceae), Shorea obtusa Wall ex Blume (Dipterocapaceae) and Haldina cordifolia (Roxb) ridsdale (Rubiaceae)

Name: Rungcharn Suksungworn

LCSH: Kasetsart University -- Dissertations. Ph.D. (Botany) 2020

Classification :.LCCS: QK495.D564

LCSH: Kasetsart University. -- Department of Botany -- Dissertatoins

LCSH: Dipterocapaceae

Abstract: A screening on the antioxidant ability on seven plant species from Thai flora revealed that Homalium bhamoense and Shorea obtusa could deliver relevant phytochemicals with bioactive properties. As both isoscopoletin and umbelliferone, isolated from Haldina cordifolia, showed a high potential to inhibit the Mimosa pigra seedling, the plant was also selected in order to investigate the biological properties and chemical profile of these collection of plants. The scope and intent of this study is divided into three chapters as follows; Chapter 1; The extract obtained from the bark of H. bhamoense significantly inhibited the inflammatory-mediating enzymes 5- lipoxygenase and hyaluronidase with concentration-dependency. A reduction in NO levels in LPS-challenged RAW 264.7 macrophages has been also recorded. HPLCDAD analysis indicate that the observed effects might derive from ellagic acid and a series of derivatives. Five constituents have been isolated from the wood extract of the plant, and were found to inhibit the enzymatic activity of α-glucosidase, α-amylase and aldose reductase, none of the constituents interfering with the cellular viability of gastric-derived AGS cells. Chapter 2; Worth to refer the antimicrobial properties towards Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Candida albicans upon exposure to a bark extract obtained from S. obtuse. Chapter 3; Coumarins obtained from Haldina cordifolia were foundt to play a role in protein expression of plant growth and development, morphological changes, Ca2+ accumulation as well as in programmed cell death.

Kasetsart University. Office of the University Library

Address: Bangkok

Email: tdckulib@ku.ac.th

Name: Sutsawat Duangsrisai

Role: Thesis Advisor

Name: Srunya Vajrodaya

Role: Thesis CO-Advisor

Name: Pakorn Wattana-amorn

Role: Thesis CO-Advisor

Name: Nelson Goncalo Mortagua Gomes

Role: Thesis CO-Advisor

Created: 2020

Modified: 2025-07-11

Issued: 2025-07-11

วิทยานิพนธ์/Thesis

application/pdf

URL: https://www.lib.ku.ac.th/KUthesis/2563/rungcharn-suk-all.pdf

CallNumber: QK495.D564 .R87

eng

DegreeName: Doctor of Philosophy

Level: Doctoral Degree

Descipline: Botany

Grantor: Kasetsart University

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