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Kanokorn Sudto. Extraction, isolation and molecular docking studies of resveratrol oilgomers from Shorea roxburghii G Don for potential antimicrobial and antitumor activities. Doctoral Degraee(Genetic Engineering). Kasetsart University. Office of the University Library. : Kasetsart University, 2019.
Extraction, isolation and molecular docking studies of resveratrol oilgomers from Shorea roxburghii G Don for potential antimicrobial and antitumor activities
Name: Kanokorn Sudto
Classification :.LCCS: QK495.D564
LCSH:
Dipterocarpaceae
LCSH:
Oligomers
LCSH:
Anti-infective agents
LCSH:
Bioactive compounds
Abstract:
In this work, five known as diptoindonesin D, hopeafuran, α-viniferan, hopeahainol A and hopeahainol C were extracted and isolated from stem bark of Shorea roxburghii G. Don. Diptoindonesin D was evaluated for its in vitro antimicrobial activity. The ECD results indicated that the possible configuration of diptoindonesin D should be R-configuration by circular dichroism (ECD) calculations. Furthermore, reverse docking was performed to identify the protein target of diptoindonesin D based on four scoring functions using GOLD program. This study is the first investigation between diptoindonesin D and its binding interaction with cell wall synthesis protein targets. The results highlighted that, penicillin-binding protein 2a (PBP2a), an antibacterial cell wall, might be the potential target for the binding of diptoindonesin D. The obtained results can be useful as a guideline for the development of effective diptoindonesin D as a PBP2a inhibitor. In addition, diptoindonesin D and hopeahainol A (from Shorea roxburghii G. Don), genetin C and anigopreissin A (from Shorea siamensis Miq) were also prepared the complexes with α-lactabumin (LA) in the molten globule (MG) state, and then tested antitumor activity on two cancer cell lines, including mouse bladder tumor cell line and human leukemia cell line (K-562). Consequently, Molecular Dynamics simulations was used to study the molecular process during unfolding to investigate the MG state of goat α-LA at high temperature at 498 K compared with αLA in native state at 298 K. Taken into account, molecular modeling is a powerful tool to identify possible protein targets and to understand insight into the interaction of a candidate for antimicrobial and antitumor development.
Kasetsart University. Office of the University Library
Address:
Bangkok
Email:
tdckulib@ku.ac.th
Name: Supa Hannongbua
Role:
Thesis Advisor
Name: Kiattawee Choowongkomon
Role:
Thesis CO-Advisor
Created:
2019
Modified:
2025-06-30
Issued:
2025-06-30
วิทยานิพนธ์/Thesis
application/pdf
URL: https://www.lib.ku.ac.th/KUthesis/2562/kanokorn-sud-all.pdf
CallNumber:
QK495.D564 .K36
eng
DegreeName: Doctor of Philosophy
Level: Doctoral Degraee
Descipline: Genetic Engineering
Grantor: Kasetsart University
©copyrights Kasetsart University
RightsAccess:
ใช้เวลา
0.029234 วินาที
Kanokorn Sudto
| Title | Contributor | Type |
|---|---|---|
| Naringin from pomelo Citrus grandis (L.) Osbeck peel
จุฬาลงกรณ์มหาวิทยาลัย Kanokorn Sudto | Supason Wanichwecharungruang | วิทยานิพนธ์/Thesis |
| Target identification of hopeahainol C for antibacterial activity
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Kanokorn Sudto;Chompoonuch Tancharoen;Darinee Phromyothin;Patchreenart Saparpakorn;Yan Hua Qin;Srunya Vajrodaya;Supanna Techasakul;Hui-Ming Ge;Ren Xiang Tan;Supa Hannongbua | บทความ/Article | |
| Extraction, isolation and molecular docking studies of resveratrol oilgomers from Shorea roxburghii G Don for potential antimicrobial and antitumor activities
มหาวิทยาลัยเกษตรศาสตร์ Kanokorn Sudto | Supa Hannongbua | วิทยานิพนธ์/Thesis |
Supa Hannongbua
Kiattawee Choowongkomon