Optimization of semha-pinas extract orodispersible tablets using response surface methodology

Name: Jirapornchai Suksaeree.

Organization : Rangsit University. College of Pharmacy

Name: Chaowalit Monton.

Organization : Rangsit University. College of Pharmacy

Email : chaowalit@rsu.ac.th

Name: Abhiruj Navabhatra.

Organization : Rangsit University. College of Pharmacy

Name: Laksana Charoenchai.

Organization : Rangsit University. College of Pharmacy

Name: Natawat Chankana.

Organization : Rangsit University. College of Pharmacy

Name: Ornchuma Naksuriya.

Organization : Rangsit University. College of Pharmacy

keyword: Box-Behnken design.

LCSH: Expectorants -- Design.

; Orodispersible tablet.

LCSH: Response surfaces (Statistics)

; Semha-pinas extract.

Abstract: The original dosage form of the Semha-Pinas herbal formula, an expectorant in Thai traditional medicine, is in a pill form. However, it is inconvenient to use because it must be powdered and dissolved in hot water or juice of Citrus x aurantium L. before use. The development of a new dosage form presents a challenging prospect. This work aimed to develop Semha-Pinas extract orodispersible tablets based on the response surface methodology using the Box-Behnken design. Firstly, Semha-Pinas extract was tested for its safety in HepG2 cells. The safe extract was further developed as orodispersible tablets. Four levels of three factors - compressional force (500-2,000 psi), the quantity of microcrystalline cellulose (0-15 percent), and the quantity of croscarmellose sodium and sodium starch glycolate (0:8-6:2 percent) - were screened using the one factor at a time technique. The Box-Behnken design has three levels for each factor: 1,000-2,000 psi, 5-15 percent, and 2:6-6:2 percent, respectively. Tablet thickness, hardness, friability, and disintegration time were the four responses that were monitored. The results indicated the safety of the Semha-Pinas extract, even at a concentration of 5 mg/mL. The optimal orodispersible tablet formulation had a compressional force of 1,500 psi, microcrystalline cellulose of 10 percent, and croscarmellose sodium to sodium starch glycolate of 4:4 percent. In summary, this study successfully fabricated Semha-Pinas extract orodispersible tablets using response surface methodology, achieving the desired property of fast disintegration. Moreover, these findings can serve as a valuable reference for pilot scale and industrial scale production."

King Mongkut's University of Technology North Bangkok. Central Library

Address: BANGKOK

Email: library@kmutnb.ac.th

Created: 2024

Modified: 2567-01-16

Issued: 2024-01-16

BibliograpyCitation : APPLIED SCIENCE AND ENGINEERING PROGRESS. vol. 17, no. 1 (Jan.-Mar. 2024), p. 1-14.

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