The comparative study of the effectiveness of the anti Inflammatory effect of 3% Andrographis paniculata versus 1% clindamycin for inflammatory acne

Comparative study of the effectiveness of the anti Inflammatory effect of 3% Andrographis paniculata versus 1% clindamycin for inflammatory acne

Name: Samak Pumampa

keyword: Anti-Inflammatory Effect

MeSH: Andrographis paniculate -- 305665

Classification :.DDC: e-Theses

; Inflammatory Acne

MeSH: Anti-inflammatory agents

MeSH: Acne

MeSH: Acne -- Treatmen -- 305666

LCSH: Andrographis paniculate -- 305665

LCSH: Anti-inflammatory agents

LCSH: Acne

LCSH: Acne -- Treatmen -- 305666

Abstract: Background: Andrographis paniculata Nees has been used as a traditional medicine in many countries. The active components of A. paniculata are called diterpene lactones. Andrographolide (AP2) is the most active component of this plant which exhibits analgesic and anti-inflammatory effects. Cutibacterium acne plays an important role in the inflammatory process which is a main pathogenic factor. This knowledge suggests that andrographolide might be useful in the treatment of acne vulgaris. Objective: To study the effectiveness of anti-inflammatory effect 3% Andrographis paniculata extract versus 1% Clindamycin topical solution for inflammatory acne. Material & Methods: This research is blinded randomized, investigator, comparative clinical trial, intra-individual split-face comparison with 16 participants and the duration of 12-week period. The study population is healthy male and female between 18-40 years old with mild to severe acne were enrolled in this study. All participants are randomly allocated to receive 3%Andrographis paniculata extract on one side of the face, while the other side serves as 1%clindamycin topical solution. Clinical evaluation included acne severity grading, inflammatory and non-inflammatory acne lesion counting, adverse events evaluation including erythema, scaling, dryness, stinging/burning and itching at the baseline, 4-week, 8-week, and 12- week visit. Patient’s satisfaction score evaluation at 12-week visit. Results: 1% Clindamycin topical solution had better effectiveness and satisfaction score at week-12 visit with no statistically significant (p-value = 0.524 and 0.847 respectively). Reduction of IGA score between 2 groups has shown no differences. 4 subjects from each group had 1 level reduction of IGA score at week 12 with no statistically significant (p-value = 1.00). For adverse events between 2 groups. 1%Clindamycin topical solution group caused more adverse events than 3%Andrographis panicualata extract group. Nine participants from 1%clindamycin topical solution group developed dry skin with statistically significant. (p-value = 0.027). Conclusion: 3%Andrographis panicualata extract has shown the effectiveness in treatment of mild to severe acne vulgaris, despite 1%Clidamycin topical solution had more effectiveness in reduction of inflammatory lesions and patients’ satisfaction score. Therefore 3%Andrographis paniculata extract can be considered as an alternative treatment in acne patients who are concerned with bacterial resistance either alone or in adjunctive with other topical agents.

Mae Fah Luang University. Learning Resources and Educational Media Center

Address: CHIANG RAI

Email: library@mfu.ac.th

Name: Rassapoom Sumaetheiwit

Role: Advisor

Created: 2022

Modified: 2023-07-25

Issued: 2023-07-25

วิทยานิพนธ์/Thesis

application/pdf

CallNumber: e-Theses

eng

DegreeName: Master of Science

Level: Master's Degree

Descipline: Dermatology

Grantor: Mae Fah Luang University

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