Development of anti-acne soap containing Mimosa pudica L. extract

Name: Tanyarat Sutti

ThaSH: Mimosa

ThaSH: Mimosa pudica L. extract

ThaSH: Antibacterial activity

ThaSH: Anti-acne soap

Abstract: Mimosa pudica L. or sensitive plant is a pantropical weed that could be found in Asian countries including Thailand. This plant belongs to Fabaceae family and could be used as a traditional medicine to treat diarrhea, insomnia, headache, fever, and skin conditions. Some studies reported the presence of various bioactive compounds in this plant especially phenolic compounds. In this study, the investigation of total phenolic content and its antioxidant potential of M. pudica L. extract (MPE) were performed using Folin-Ciocalteu method and DPPH assay, respectively. Moreover, its antibacterial susceptibility against Straphylococcus aureus (S. aureus), Straphylococcus epidermidis (S. epidermidis) and Cutibacterium acnes (C. acnes) were also determined using disk diffusion method, and minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined using standard broth dilution technique. The results showed that, MPE which soaked in 95% ethanol (MPE95E) exhibited the highest percent yield (16.64 %w/w), with highest amount of phenolic compounds (137.73 ± 0.69 mg GAE/g) and exhibited the highest free radical scavenging activity with IC50 value of 22.15 ± 0.03 µg/mL as compared with other samples, MPE soaked in water (MPEwater) and 70% ethanol (MPE70E). Furthermore, the MIC of MPE95E against both S. aureus and S. epidermidis were 7.5 mg/mL, while C. acnes was 30 mg/mL. In addition, MBC of MPE95E against both S. aureus and S. epidermidis were 30 mg/mL, while C. acnes was more than 30 mg/mL, respectively. These results suggested that M. pudica L. could be a potential source of antioxidant with free radical scavenging and antibacterial activity which will be useful for development of anti-acne cosmetic products. MPE95E was selected to use as an active ingredient to develop soap bar formulation. MPE beads using encapsulation technique and MPE solutions using solubilizer were prepared to improve solubility of the extract. Then, glycerin soap bars containing MPE were developed. Anywise, glycerin soap bars containing MPE beads were shown uneven beads dispersed in that soaps, but soaps containing MPE solutions were homogeneously the whole bar with green color of extract. Finally, MPE beads, MPE solutions, and glycerin soap bars containing MPE solutions were used for stability testing. The results suggested that MPE alginate beads dispersed in medium were more stable than without medium. MPE solutions were shown not changed in viscosity at room temperature, while a bit higher and lower viscous liquid were observed at 4°C and 45°C, respectively. However, the results of stability test of glycerin soap bars containing MPE exhibited homogeneous with green color, enough foam volume, and good foam stability. The pH values of these formulations were in the range of 9.21 - 9.38 with minimum corrosive value. All results were acceptable according to the criteria of Thai Community Product Standards 665/2553 (glycerin soap bar), Ministry of Industry, Thailand. And most importantly, glycerin soap bar containing MPE showed effectively against S. aureus, S. epidermidis, and C. acnes. It could be suggested that this product would be attractive in daily life using for everyone in the future.

NARESUAN UNIVERSITY. NARESUAN UNIVERSITY LIBRARY

Address: PHITSANULOK

Email: library@nu.ac.th

Name: Jarupa Viyoch

Role: Assistant Professor

Created: 2566

Modified: 2023-04-25

Issued: 2023-04-25

วิทยานิพนธ์/Thesis

application/pdf

eng

DegreeName: Master of Science

Level: Master's degree

Descipline: Cosmetic Science

Grantor: มหาวิทยาลัยนเรศวร

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