PEG-containing amphiphilic copolymers: preparation by postpolymerization modification and micelles formation

Name: Susita Noree

Organization : Chulalongkorn University. Faculty of Science

Name: Varawut Tangpasuthadol

Organization : Chulalongkorn University. Faculty of Science

Name: Voravee P. Hoven

Organization : Chulalongkorn University. Faculty of Science

Email : vipavee.p@chula.ac.th

keyword: Copolymers

LCSH: Polyethylene glycol

; Poly(pentafluorophenyl acrylate)

LCSH: Polymerization

Abstract: Amphiphilic random copolymer designed to be used as drug carrier were prepared via post-polymerization modification of poly(pentafluorophenyl methacrylate) (PPFPMA) with poly(ethylene glycol) methyl ether amine (PEG-NH2). PPFPMA was first synthesized using reversible addition−fragmentation chain transfer polymerization (RAFT). The pentafluorophenyl (PFP) active ester groups of the PPFPMA reacted with the PEG-NH2 and yielded PEG-containing amphiphilic copolymer (P(PFPMA-co-PEGMAM). The composition of PEG in the copolymer was varied from 27 to 54 and 74%. The size of micelles selfassembled from the copolymer in water was found to increase with the increasing PEG composition in a range of 80-600 nm. It is our on-going effort to introduce cleavable dithiol crosslinking to the micelles via tandem post-polymerization modification of the remaining PFP active ester groups in the copolymer with cystamine. The ability to encapsulate a hydrophobic dye by the micelles is also explored

King Mongkut's University of Technology North Bangkok. Central Library

Address: BANGKOK

Email: library@kmutnb.ac.th

Created: 2016

Modified: 2023-01-09

Issued: 2023-01-09

BibliograpyCitation : In Chemical Society of Thailand under the Patronage of Professor Dr. HRH Princess Chulabhorn and Chulalongkorn University Faculty of science. Pure and Applied Chemistry International Conference (PACCON 2016) (pp.1345-1350). Bangkok : Chemical Society of Thailand under the Patronage of Professor Dr. HRH Princess Chulabhorn

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