The Effects of Oral Combined Nutraceuticals on Skin Health in Post - Menopausal Women

Name: Pakagamon Tumsutti

LCSH: Menopause -- Hormone therapy -- Research

LCSH: Skin -- Care and hygiene -- Research

LCSH: Estrogen -- Therapeutic use -- Research

Abstract: Skin aging is one of the most concerned issues that occur during post-menopausal period, mainly due to estrogen deficiency and reactive oxygen species. Despite the promising effects of hormonal replacement therapy on improving skin quality, a handful amount of post-menopausal women are still concerned about the long-term adverse outcomes those could occur following the treatment. Therefore, nutraceuticals that contain estrogenic and anti-oxidative effects have gained a lot of attention as a possible alternative therapy for reversing skin aging in post-menopausal women. The objective of this study was to evaluate the efficacy and the safety of combined nutraceuticals in improving skin health, anti-oxidant level, and oxidative stress status in post-menopausal women. The study design was randomized, double-blinded, placebo-controlled clinical trial. One hundred and ten post-menopausal women aged 45-60 years old were enrolled and randomly assigned into treatment group and placebo group, equally. Combined nutraceuticals containing 100 mg of soy isoflavones, 80 mg of black cohosh, 40 mg of chasteberry, and 500 mg of evening primrose oil, were administered 1 capsule per day for 12 weeks in the treatment group, while the another group received a placebo. Skin elasticity, hydration, transepidermal water loss (TEWL), gloss, melanin index, smoothness, roughness, scaliness, and wrinkles were evaluated at baseline, week 6, and week 12 of the study. Additionally, reduced glutathione (GSH) and malondialdehyde (MDA) level were measured at baseline and week 12 to evaluate the improvement in anti-oxidant and oxidative stress status. The results of this study showed that at week 6, the skin roughness was the only parameter that significantly improved in the treatment group. At the end of the study, however, there were significant differences between the treatment group and the control group, and also a significant intragroup improvement in the treatment group, regarding effects on skin elasticity, skin roughness, skin smoothness, skin scaliness, and wrinkles. Meanwhile, no significant improvement in skin hydration, TEWL, melanin index, and skin gloss was observed in both groups. For the evaluation of anti-oxidant and oxidative stress status, both GSH and MDA levels were found to be significantly improved in the treatment group at the end of the study. In conclusion, this study suggests that the intake of these combined nutraceuticals containing soy isoflavones, black cohosh, chasteberry, and evening primrose oil can lead to not only the improvement in several aspects of skin health, but also the improvement in anti-oxidant level, as well as oxidative stress status in post-menopausal women.

Dhurakij Pundit University. Learning Center and Library.

Address: BANGKOK

Email: library@dpu.ac.th

Name: Pansak Sugkraroek

Role: Thesis Advisor

Modified: 2564-05-28

Created: 2019

Issued: 2021-05-25

วิทยานิพนธ์/Thesis

application/pdf

eng

DegreeName: Master of Science

Descipline: Anti-Aging and Regenerative Medicine

Grantor: Dhurakij Pundit University

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