Abstract:
Uncontrolled hemorrhage is a major surgical complication. The excessive hemorrhage usually requires an intensive care stay and causes higher mortality and morbidity of patients. In order to rapidly control a hemorrhage, sprayable hydrogels are promising to gently seal injured tissues with biomimetic physical and chemical properties, which can be tuned by modifying the hydrogel three-dimensional networks with selected molecules. Herein, we propose to fabricate sprayable poly(ethylene glycol) hydrogels via pH-responsive supramolecular crosslink made of tannic acid, Fe(III), and polymer chains. Mechanical properties of the hydrogels are assessed and adjusted to mimic biological tissues. The overall mechanical properties of the sprayable hydrogels show their great potential as biomaterials for controlling hemorrhage
King Mongkut's University of Technology North Bangkok. Central Library
Address:
BANGKOK
Email:
library@kmutnb.ac.th
Created:
2019
Modified:
2019-10-11
Issued:
2019-10-11
BibliograpyCitation :
In Chemical Society of Thailand under the Patronage of Professor Dr. HRH Princess Chulabhorn. Pure and Applied Chemistry International Conference 2019 (PACCON 2019) (O1-4). Bangkok : Mahidol University