แจ้งเอกสารไม่ครบถ้วน, ไม่ตรงกับชื่อเรื่อง หรือมีข้อผิดพลาดเกี่ยวกับเอกสาร ติดต่อที่นี่ ==>
หากไม่มีอีเมลผู้รับให้กรอก thailis-noc@uni.net.th
หากไม่มีอีเมลผู้รับให้กรอก thailis-noc@uni.net.th
Aphichart Karnchanatat. Optimization of shiitake mushroom (lentinula edodes) hydrolysate with angiotensin I converting enzyme inhibitory activity. (). King Mongkut's University of Technology North Bangkok. Central Library. : , 2019.
Optimization of shiitake mushroom (lentinula edodes) hydrolysate with angiotensin I converting enzyme inhibitory activity
Name: Supawee Paisansak
Organization :
Chulalongkorn University. Faculty of Science
Email :
Supawee_teak@hotmail.com
Name: Papassara Sangtanoo
Organization :
Chulalongkorn University. Institute of Biotechnology and Genetic Engineering
Email :
Papassara.S@chula.ac.th
Name: Aphichart Karnchanatat
Organization :
Chulalongkorn University. Institute of Biotechnology and Genetic Engineering
Email :
Aphichart.K@chula.ac.th
LCSH:
Shiitake
LCSH:
Hydrolysis
Abstract:
Angiotensin-I converting enzyme is a key enzyme in regulating blood pressure. It converts angiotensin-I into angiotensin-II, which results in raised blood pressure. Inhibition of ACE leads to decrease concentration of angiotensin-II and results in blood pressure lowering. Food protein-derived ACE inhibitory peptides have been considered as a safer alternative to antihypertensive drugs. Shiitake, one of the most consumed mushrooms in Thailand, is recognized as a nutritive food ingredient with health-stimulating properties. The aim of this study was to optimize the preparation of shiitake-protein hydrolysate and its ACE inhibitory activity. Shiitake mushroom was hydrolyzed by alcalase using response surface methodology (RSM). The degree of hydrolysis (DH) and ACE inhibitory activity were monitored. The optimum conditions, under which the DH was maximized to 28.88 percent, were 50.2 Celsius degrees, 3 hours hydrolysis time, and 1.16 enzyme per substrate ratio. However, the optimum conditions, under which the hydrolysate exhibited the highest ACE inhibitory activity were under 47 Celsius degrees, 3 hours 28 minutes hydrolysis time, and 0.59 enzyme per substrate ratio. The highest activity was fractionated into 5 ranges of molecular weight, and the fraction below 0.65 KDa showed the highest activity with IC50 of 0.23 ug per mL. Consequently, peptides from Shiitake mushroom would be a beneficial ingredient for pharmaceuticals and functional food against hypertension
King Mongkut's University of Technology North Bangkok. Central Library
Address:
BANGKOK
Email:
library@kmutnb.ac.th
Created:
2019
Modified:
2019-09-30
Issued:
2019-09-30
บทความ/Article
application/pdf
BibliograpyCitation :
In Chemical Society of Thailand under the Patronage of Professor Dr. HRH Princess Chulabhorn. Pure and Applied Chemistry International Conference 2019 (PACCON 2019) (FA125-132). Bangkok : Mahidol University
eng
©copyrights King Mongkut's University of Technology North Bangkok
RightsAccess:
ใช้เวลา
0.037116 วินาที
Supawee Paisansak
| Title | Contributor | Type |
|---|---|---|
| Optimization of shiitake mushroom (lentinula edodes) hydrolysate with angiotensin I converting enzyme inhibitory activity
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Supawee Paisansak;Papassara Sangtanoo;Aphichart Karnchanatat | บทความ/Article | |
| Optimization Of Protein Hydrolysate Preparation And Their Angiotensin I-Converting Enzyme Inhibitory Activity From Shiitake Mushrooms Lentinula Sp.
จุฬาลงกรณ์มหาวิทยาลัย Supawee Paisansak | Aphichart Karnchanatat | วิทยานิพนธ์/Thesis |
Papassara Sangtanoo
| Title | Contributor | Type |
|---|---|---|
| Free radical scavenging properties and DNA damage protecting of peptide hydrolysate derived from edible mushroom Astraeus hygrometricus
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Natpatsorn Tunyatarinun;Onrapak Reamtong;Papassara Sangtanoo;Tanatorn Saisavoey;Aphichart Karnchanatat | บทความ/Article | |
| Optimization of preparing protein hydrolysate from Split Gill mushroom (Schizophyllum commune) by alcalase using response surface methodology (RSM)
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Aunchalee Wongaem;Papassara Sangtanoo;Aphichart Karnchanatat | บทความ/Article | |
| Optimization of shiitake mushroom (lentinula edodes) hydrolysate with angiotensin I converting enzyme inhibitory activity
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Supawee Paisansak;Papassara Sangtanoo;Aphichart Karnchanatat | บทความ/Article |
Aphichart Karnchanatat