Lalita Chunkoh.. Accuracy of computed tomography for common neurological disease in HIV patients at Siriraj hospital. Master's Degree(Radiological Science). Mahidol University. Mahidol University Library and Knowledge Center. : Mahidol University, 2015.
Accuracy of computed tomography for common neurological disease in HIV patients at Siriraj hospital
Abstract:
Our study has collected CT brain images of 139 HIV patients in Siriraj hospital since 2008 to 2013. We used the image data of CT brain in pre-contrast and post-contrast for diagnosis common neurological disease in HIV patients. The accuracy of the study was ensured by using data correlation between imaging and blood histochemistry laboratory data. The accuracy of Computed Tomography was calculated for sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV). The study population included of 93 male and 46 females. The patients age ranged from 10 to 71 years. Common neurological disease in HIV patients were Cryptococcal meningitis (46 patients, 32.6%), followed by Tuberculous meningitis (45 patients, 32.4%), HIV encephalopatchy or HIVE (37 patients, 26.6%), Toxoplasmosis (20 patients, 14.4%), Progressive multifocal leukoencephalopathy or PML (13 patients, 9.4%), Primary CNS Lymphoma or PCNSL (9 patients, 6.5%), Other (Brain metastasis, Intracerebral hemorrhage, Meningitis and Kaposi sarcoma) (5 patients, 3.6%), Tuberculomas (4 patients, 2.9%), and Cryptococcomas (3 patients, 2.2%), respectively. The Accuracy of common neurological disease was 68.3, 74.1, 56.8, 89.0, 93.5, 97.8, 96.4, 92.8 and 96.4 respectively. CT was found the most accuracy to have sensitivity, specificity, PPV and NPV for PCNSL (77.8%, 99.2%, 85.7% and 98.5%), respectively. Cryptococcal meningitis, Tuberculous meningitis and HIVE were common neurological diseases to have high prevalence in HIV patients. The most accuracy of CT was showed with space occupying lesion such as PCNSL, PML, Toxoplasmosis, Tuberculomas and Cryptococcomas followed by Cryptococcal meningitis, Tuberculous meningitis and HIVE.
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