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Narongdech Khobsantia. Structural analysis and Fmoc-Leu-Asn-Phe-OMe tripeptide binding properties of betulinic acid and its derivative. (). King Mongkut's University of Technology North Bangkok. Central Library. : , 2017.
Structural analysis and Fmoc-Leu-Asn-Phe-OMe tripeptide binding properties of betulinic acid and its derivative
Name: Korakot Navakhun
Organization :
Ramkhamhaeng University. Faculty of Science
Email :
n_korakot@ru.ac.th
Name: Narongdech Khobsantia
Organization :
Ramkhamhaeng University. Faculty of Science
keyword:
Betulinic acid
Abstract:
Betulinic acid (1) is a naturally occurring pentacyclic triterpene alcohol with a lupane
skeleton. Betulinic acid and its derivatives have shown various interesting pharmacological
properties including anti-HIV activity. The structures of betulinic acid (1) and acetylbetulinic
acid (2) were investigated via the computational method using the density functional theory
(DFT) at the B3LYP/6-31G(d) level. The results showed good agreement with experimental data
of compound 1 obtained using X-ray single crystal spectroscopy technique. They were
computed for geometry optimizations and studied for binding properties with the N-termini of
HIV-1 Protease mimic, Fmoc-Leu-Asn-Phe-OMe (3) as a protected tripeptide, at the B3LYP/6-
31G(d) level in gas phase. It has been found that betulinic acid bounds this tripeptide more
selectively than its derivative.
King Mongkut's University of Technology North Bangkok. Central Library
Address:
BANGKOK
Email:
library@kmutnb.ac.th
Created:
2017
Modified:
2562-08-15
Issued:
2019-08-15
บทความ/Article
application/pdf
BibliograpyCitation :
In Chemical Society of Thailand under the Patronage of Her Royal Hghness Princess Chulabhorn Mahidol and King Mongkut's University of Technology North Bangkok Faculty of Applied Science. Pure and Applied Chemistry International Conference (PACCON 2017) (pp.956-960). Bangkok : Chemical Society of Thailand under the Patronage of Her Royal Hghness Princess Chulabhorn Mahidol
eng
©copyrights King Mongkut's University of Technology North Bangkok
RightsAccess:
ใช้เวลา
0.028063 วินาที
Korakot Navakhun
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