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Chutima Phechkrajang. Development and validation of a stability indicating HPLC method for determination of doxycycline hyclate in bulk and capsules. (). King Mongkut's University of Technology North Bangkok. Central Library. : , 2017.
Development and validation of a stability indicating HPLC method for determination of doxycycline hyclate in bulk and capsules
Name: Phennapha Chancharoen
Organization :
Mahidol University. Faculty of Pharmacy
Name: Leena Suntornsuk
Organization :
Mahidol University. Faculty of Pharmacy
Name: Piyanuch Rojsanga
Organization :
Mahidol University. Faculty of Pharmacy
Name: Chutima Phechkrajang
Organization :
Mahidol University. Faculty of Pharmacy
Email :
phennaphaaa@gmail.com
keyword:
Doxycycline hyclate
LCSH:
Hydrolysis
Abstract:
A stability indicating reverse phase high performance liquid chromatography (RP
HPLC) method was developed for the determination of doxycycline hyclate in bulk and
capsules to support product development and quality control. Chromatographic separation of
doxycycline hyclate and its degradation products was achieved on a Symmetry® C8 column
(150 mm x 4.6 mm, 5 μm). An isocratic mobile phase was employed with the mixture of
water and acetonitrile, 88:12 (v/v) (pH adjusted to 3.00 with phosphoric acid) at a flow rate of
1.0 mL/min. The detection was carried out by UV detection at 273 nm. Doxycycline hyclate
was subjected to stress conditions including hydrolysis (neutral, acidic and alkaline),
oxidation, photolysis and thermal conditions. Significant degradation was observed in
hydrolysis (neutral, acidic and alkaline) and oxidative conditions. The method was validated
by evaluating linearity and range, accuracy, precision and specificity according to the ICH
guideline.
King Mongkut's University of Technology North Bangkok. Central Library
Address:
BANGKOK
Email:
library@kmutnb.ac.th
Created:
2017
Modified:
2562-07-22
Issued:
2019-07-22
บทความ/Article
application/pdf
BibliograpyCitation :
In Chemical Society of Thailand under the Patronage of Her Royal Hghness Princess Chulabhorn Mahidol and King Mongkut's University of Technology North Bangkok Faculty of Applied Science. Pure and Applied Chemistry International Conference (PACCON 2017) (pp.26-32). Bangkok : Chemical Society of Thailand under the Patronage of Her Royal Hghness Princess Chulabhorn Mahidol
eng
©copyrights King Mongkut's University of Technology North Bangkok
RightsAccess:
ใช้เวลา
0.042547 วินาที
Phennapha Chancharoen
| Title | Contributor | Type |
|---|---|---|
| Development and validation of a stability indicating HPLC method for determination of doxycycline hyclate in bulk and capsules
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Phennapha Chancharoen;Leena Suntornsuk;Piyanuch Rojsanga;Chutima Phechkrajang | บทความ/Article |
Leena Suntornsuk
| Title | Contributor | Type |
|---|---|---|
| Development and validation of a stability indicating HPLC method for determination of doxycycline hyclate in bulk and capsules
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Phennapha Chancharoen;Leena Suntornsuk;Piyanuch Rojsanga;Chutima Phechkrajang | บทความ/Article |
Piyanuch Rojsanga
| Title | Contributor | Type |
|---|---|---|
| Development and validation of a stability indicating HPLC method for determination of doxycycline hyclate in bulk and capsules
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Phennapha Chancharoen;Leena Suntornsuk;Piyanuch Rojsanga;Chutima Phechkrajang | บทความ/Article | |
| Determination of mercury level in soil and food by direct mercury analyzer and risk assessment of mercury exposure using risk program
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Ratchamongkhol Pothiruk;Sawanya Buranaphalin;Nongluck Ruangwises;Piyanuch Rojsanga | บทความ/Article | |
| Bioanalytical method development and validation for determination of Rosmarinic acid in biological media using high-performance liquid chromatography
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Kotchaphan Chooluck;Chutima Phechkrajang;Piyanuch Rojsanga | บทความ/Article |
Chutima Phechkrajang
| Title | Contributor | Type |
|---|---|---|
| Development and validation of a stability indicating HPLC method for determination of doxycycline hyclate in bulk and capsules
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Phennapha Chancharoen;Leena Suntornsuk;Piyanuch Rojsanga;Chutima Phechkrajang | บทความ/Article | |
| Bioanalytical method development and validation for determination of Rosmarinic acid in biological media using high-performance liquid chromatography
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Kotchaphan Chooluck;Chutima Phechkrajang;Piyanuch Rojsanga | บทความ/Article |