Abstract:
The objectives of this study were to prepare the cuttlebone, evaluate the physicochemical properties and efficacy on inhibition of Propionibacterium acnes and synthetic sebum adsorption ability. The preparation of mask containing cuttlebone was also performed. The powder of prepared cuttlebone had the unique smell and the powder size of less than 125 micrometers. The percentage of powder preparation was 78.98 ± 1.39%. The solubility characteristic was shown the dispersibility of powder in propylene glycol and polyethylene glycol-400. The moisture content after drying was 1.14 ± 0.08 %. The angle of repose of powder was 32.29 ± 1.29 degree. The compressibility index of powder was 16.79 ± 2.92%, whereas the Hausner ratio was 1.20 ± 0.04. The water and oil adsorption values were 3.67 ± 1.53 and 27.33 ± 3.06%, respectively. The cuttlebone was not able to inhibit the bacterial growth, but it was shown the synthetic sebum adsorption ability of 70.85 ± 3.40%. The preparation of mask containing 1% cuttlebone was shown the significantly increased viscosity and pH value with p-values of 0.001 and 0.003, respectively, in compared to the mask base. After stability test with the accelerated condition, the formulation was shown the stable preparation.