Lipid Peroxidation and Scavenging Enzyme Activity in Short and Long Distance Runners

Name: Chaivat Toshulkao

Organization : Mahidol University. Faculty of Science. Department of Physiology

Name: Weerasak Ussawawongaraya

Organization : Mahidol University. Faculty of Science. Department of Physiology

Name: Atip Likidlilid

Organization : Mahidol University, Siriraj Hospital. Faculty of Medicine. Department of Biochemistry

Name: Thirayudh Glinsukon

Organization : Mahidol University. Faculty of Science. Department of Physiology

keyword: Scavenging enzyme

MeSH: Exercise

; Muscle damage

MeSH: Lipid Peroxides

Abstract: This study was designed to investigate the influence of training in short and long distance runners on the activity of scavenging enzymes such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in erythrocytes. Anthropometry, vital signs and the relationship between plasma lipid peroxide (MDA level) and muscle damage by using the activity of lactate dehydrogenase (LDH) and creatine phosphokinase (CPK) as indicators were also studied. The percent body fat and heart rate in short and long distance runners were significantly lower than those of sedentary subjects, whereas maximum oxygen consumption (V02max) in short and long distance runners was significantly higher than those of sedentary subjects. However, heart rate and leg strength in short distance runners were significantly different from those of sedentary subjects and long distance runners. Our results suggested that both short and long distance runners who followed training programmes of 3-4 h/day and 4-6 days/week for 3.1 years had greater physical fitness than sedentary subjects. No significant difference was detected in the activity of SOD, CAT and GSH-Px enzymes in short and long distance runners. CAT and GSH-Px activity in short and long distance runners was Significantly higher than in sedentary subjects whereas SOD activity was significantly increased only in long distance runners. Plasma LDH and CPK activity and lipid peroxide level in short and long distance runners were significantly higher than in sedentary subjects. These results indicated that there was an intensity-response relationship between increased lipid peroxide formation and muscle damage after exercise and exercise training caused an adaptation of the activity of scavenging enzymes.

Mahidol University. Mahidol University Library and Knowledge Center

Address: NAKHONPATHOM

Email: liwww@mahidol.ac.th

Created: 2013

Modified: 2013-03-08

Issued: 1998-01/06

บทความ/Article

application/pdf

Mahidol Journal. 5, 1 (Jan.-June 1998) 1-4

eng

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