The efficacy of 3% L-carnitine gel for facial sebum and pore size reduction

Efficacy of 3% L-carnitine gel for facial sebum and pore size reduction

Name: Khin Hnin Su Wai

keyword: L-carnitine

MeSH: Carnitine

Classification :.DDC: e-Theses

; Enlarged Pores

MeSH: Sebum -- 200662

MeSH: Face -- Care and hygiene -- 17066

MeSH: Skin

LCSH: Carnitine

LCSH: Sebum -- 200662

LCSH: Face -- Care and hygiene -- 17066

LCSH: Skin

Abstract: Background: Oily skin condition and facial pores are common undesirable condition which attributes to significant cosmetic concern because female patients are complaining of difficulty in applying make-up because of roughened greasy skin with enlarged pores especially seen in the T-zone. Three main factors contributing to the pathogenesis of enlarged facial pores are seborrhea, loss of skin elasticity and tension, and size of hair follicle. L-carnitine or Carnitine (-hydroxy--N-trimethylaminobutyric acid) is a substance which has been gaining attention and studies proved in terms of ability to reduce the facial sebum production. Another study has shown that compared to hydroxy acids like AHA and PHA, Carnitine showed higher exfoliating effect with neutral to slightly acidic pH thereby, improving dullness of skin, mild acne, fine wrinkles and pores due to the exfoliating property in the field of cosmetics. There will be a new alternative treatment for enlarged pores with oily skin if this study is expected to be resulted in significant sebum and pore size reduction. Objective: To determine the efficacy of 3% L-carnitine gel in sebum level production and pore size reduction Materials & Methods: This research is an Open Label Quasi Experimental Clinical Controlled Study involving participants aged between 20-45 years old and the duration of study is 12 weeks. Total of 18 female healthy volunteers who met the criteria are asked to apply 3% L-carnitine gel on the whole face twice daily for 12 weeks. For the assessment of the efficacy of 3% L-carnitine gel, particular areas of oily face such as forehead, nose and cheek areas are measured by Sebumeter SM 815 and the photography with VISIA Complexion Analysis System are compared at Week 0, 4, 8, and 12. Physician will assess to detect any side effects and questionnaires are given out to evaluate patients’ satisfaction. Results: 16 participants completed the study and the final outcomes of the mean change of sebumeter score and pore score were statistically significant (p value<0.001) in follow-up visits, thus, reducing sebum production and improving the appearance of pores. In addition, 3% L-carnitine gel also has high patients’ satisfaction score and well tolerated by the patients without adverse effects. Conclusion: This study concluded 3% L-carnitine gel has better efficacy to reduce both sebum level and pore size, being a coenzyme of Acetyl CoA, which plays important role in fatty acid -oxidation and due to its exfoliating property. Hence, it is believed that topical 3% L-carnitine can safely be used as an alternative treatment for oily face with enlarged pores.

Mae Fah Luang University. Learning Resources and Educational Media Center

Address: CHIANG RAI

Email: library@mfu.ac.th

Name: Tanomkit Pawcsuntorn

Role: Advisor

Created: 2023

Modified: 2024-01-18

Issued: 2024-01-18

CallNumber: e-Theses

eng

DegreeName: Master of Science

Level: Master's Degree

Descipline: Dermatology

Grantor: Mae Fah Luang University

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